The polycomb-group (PcG) proteins function as general regulators of stem cells.We previously reported that retrovirus-mediated overexpression of Bmi1, a gene encoding a core component of polycomb repressive complex (PRC) 1, maintained Stylus Pressure Gauge self-renewing hematopoietic stem cells (HSCs) during long-term culture.However, the effects o
Background/Objectives: Endophthalmitis is an intraocular microbial infection that can lead to permanent blindness, even with prompt anti-microbial therapy.Multi-drug-resistant organisms are on the rise, potentially limiting the efficacy of current empiric antibiotic therapies of intravitreal ceftazidime and vancomycin.Cefiderocol is a recent FDA- a
Sonoporation, or the use of ultrasound in the presence of cavitation nuclei to induce plasma membrane perforation, is well considered as an emerging physical approach to facilitate the delivery of drugs and genes to living cells.Nevertheless, this emerging drug delivery paradigm has not yet reached widespread clinical use, because the efficiency of